I haven't done much chest running, but on occasion I've gone for the ones in Melandru's Hope, usually exiting southwest from Jade Flats (Kurzick). As I recall, there tend to be around three chests there each time, and the Dredge patrols in most of the region aren't so difficult to avoid. However, when I go, I always take Heroes because I find that some fighting needs to be done now and then. If you are used to running, then you'd probably be fine as is.
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